Taeghwan Hyeon

Director of Center for Nanoparticle Research, Institute for Basic Science (IBS)
Associate Editor of J. Am. Chem. Soc.
SNU Distinguished Fellow (Distinguished University Professor), Seoul National University

Designed Chemical Synthesis and Assembly of Uniform-sized Nanoparticles for Medical and Energy Applications
Abstract No. : PL_06
Date & Time : Dec. 9 (Wed), 11:15-12:00
Place : Ballroom 1
Name : Taeghwan Hyeon
Affiliation : Seoul National University
Chair : Seok-Cheol Hong (Korea Univ.)
Over the last 10 years, our laboratory has focused on the designed chemical synthesis, assembly and applications of uniform-sized nanocrystals. In particular, we developed a novel generalized procedure called as the “heat-up process” for the direct synthesis of uniform-sized nanocrystals of many metals, oxides, and chalcogenides.1
Recently our group has been focused on medical applications of various uniform-sized nanoparticles. Using 3 nm-sized iron oxide nanoparticles, new non-toxic MRI contrast agent was realized for high resolution MRI of blood vessels down to 0.2 mm.2We reported the first successful demonstration of high-resolution in vivo three-photon imaging using biocompatible and bright Mn2+ doped ZnS nanocrystals.3We fabricated tumor pH-sensitive magnetic nanogrenades composed of self-assembled iron oxide nanoparticles and pH-responsive ligands for theranostic application, enabling the visualization of small tumors of <3 mm via pH-responsive T1 MRI and fluorescence imaging and superior photodynamictherapeutic efficacy in highly drug-resistant heterogeneous tumors.4We synthesized tumor pH-sensitive nanoformulatedtriptolide coated with folate targeting ligand to treathepatocellular carcinoma (HCC), which has one of the worst prognosis for survival as it is poorly responsive to both conventional chemotherapy and mechanism directed therapy.
We reportedthelarge-scale synthesis of magnetite nanocrystalsimbedded in a carbon matrix and hollow iron oxide nanoparticles. We demonstrated galvanic replacement reactions in metal oxide nanocrystals. When Mn3O4 nanocrystals were reacted with iron(II) perchlorate, hollow box-shaped nanocrystals of Mn3O4/γ-Fe2O3 (“nanoboxes”) were produced.5 These iron oxide-based nanomaterials exhibited very high specific capacity and good cyclability for lithium ion battery anodes.

1."Ultra-Large Scale Syntheses of Monodisperse Nanocrystals," Nature Mater. 2004, 3, 891.
2. “Large-scale Synthesis of Uniform and Extremely Small-sized Iron Oxide Nanoparticles for High-resolution T1 MRI Contrast Agents,”J. Am. Chem. Soc.2011, 133, 12624.
3. “High-Resolution Three-Photon Biomedical Imaging using Doped ZnS Nanocrystals,”Nature Mater.2013, 12, 359.
4. “Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors,” J. Am. Chem. Soc.2014, 136, 5647.
5. “Galvanic Replacement Reactions in Metal Oxide Nanocrystals,” Science2013, 340, 964.Highlighted in “Perspectives: All Change for Nanocrystals,” Science2013, 340, 935.